Eur J Pediatr. Aug;(8) Epub Jun 4. Periventricular leucomalacia: a review. Blumenthal I(1). Author information: (1)The Royal Oldham. During an 18 month period, preterm infants of 34 weeks’ gestation or less were prospectively examined for periventricular leucomalacia (PVL) by cerebral. Periventricular leucomalacia is the term used to describe cerebral infarctions occurring near the lateral ventricles in neonates. The lesion was first described by.

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Children and adults may be quadriplegicexhibiting a loss of function or paralysis of all four limbs. National Institutes of Health Web Site.

Image from Gray’s Anatomyedition. It has also been suggested that avoiding maternal cocaine usage and any maternal-fetal blood flow alterations can decrease the risk of PVL. As previously described, the highest frequency of PVL is seen in premature, very low birth weight infants.

Periventricular leukomalacia

Those with white matter injury often exhibit “tight coupling” of leg joints all extending or all flexing much longer than other infants premature and full-term. Gray baby syndrome muscle tone Congenital hypertonia Congenital hypotonia. Dev Med Child Neurol. Two major factors appear to be involved in the development of PVL: Vertically transmitted infection Neonatal perriventricular Congenital rubella syndrome Neonatal herpes simplex Mycoplasma hominis infection Ureaplasma urealyticum infection Omphalitis Neonatal sepsis Group B streptococcal infection Neonatal conjunctivitis.


Pneumopericardium Persistent fetal circulation. This page was last edited on 21 Decemberat Unfortunately, there are very few population-based studies on the frequency of PVL.

Periventricular leucomalacia and neurodevelopmental outcome in preterm infants.

By using this site, you agree to the Terms of Use and Privacy Policy. Developmental and neurological progress of preterm infants with intraventricular haemorrhage and ventricular dilatation. Loading Stack – 0 images remaining.

Many infants with PVL eventually develop cerebral palsy. Infants with PVL often exhibit decreased abilities to maintain a steady gaze on a fixed object and create coordinated eye movements.

Correlation periventriculxr ultrasound, clinical, and nuclear magnetic resonance functions” Free full text. Support Center Support Center. Miscarriage Perinatal mortality Stillbirth Infant mortality Neonatal withdrawal.

Articles Cases Courses Quiz. Clinical assessment of gestational age in the newborn infant. The examination also imparts no radiation exposure. Ileus Peruventricular enterocolitis Leucoomalacia peritonitis.

MRI T1 Case 1: Umbilical cord prolapse Nuchal cord Single umbilical artery. Progressive necrosis of the periventricular tissue with resulting enlargement of the ventricles is called end-stage PVL.

Vlasyuk first revealed the high incidence of optic radiation lesions and demonstrated that PVL – a persistent process that the old necrosis can join a new, foci of PVL may be at different stages of development.

Robbin’s Review of Pathology.


Pperiventricular of ultrasound, clinical, and nuclear magnetic resonance functions. Minor white matter damage usually is exhibited through slight developmental delays and deficits in posture, vision systems, and motor skills.

Drawing of the lateral and third ventricles of the brain. During an 18 month period, preterm infants of 34 weeks’ gestation or less were prospectively examined for periventricular leucomalacia PVL by cerebral ultrasound. Although no treatments have been approved for use in human PVL patients, a significant amount of research is occurring in developing treatments for protection of the nervous system.

The New Periventricu,ar Journal of Medicine.

Periventricular leucomalacia is a condition pericentricular causes lifelong disability perivrntricular considerable economic burden. Tumanov [3] in published the world’s first monograph devoted to PVL. Intrauterine hypoxia Infant respiratory distress syndrome Transient tachypnea of the newborn Meconium aspiration syndrome pleural disease Pneumothorax Pneumomediastinum Wilson—Mikity syndrome Bronchopulmonary dysplasia. Those generally considered to be at greatest risk for PVL are premature, very low birth-weight infants.

Many studies examine the trends in outcomes of individuals with PVL: Thank you for updating your details.