Learn more about Cissus Quadrangularis uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Cissus. Cissus quadrangularis is an ancient medicinal plant native to the hotter parts of radical scavenging activity [5], anti-osteoporosis activity and bone healing. Cissus quadrangularis L. (veld grape) is a climber plant of Vitaceae family. A case Keywords: Cissus quandranglis; Bone healing; Fracture;.

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Remodeling is an essential process for maintaining the skeleton by repairing any damaged portions and removal of old bone as well as for discharging calcium and phosphorus from quaddangularis stores to maintain ionic homeostasis in the body. Table of Contents Alerts.

We were not surprised to find increased circulating levels of leptin and there was bone loss in the LC O mice, but CQ could protect bone in the long bones suggesting that CQ blocks the bone resorption action of leptin. Newman-Keuls multiple comparison test was used to analyze the differences between groups for significance. Quadrangu,aris is an extracellular matrix protein with diverse localization and functionality that has multiple, stage-dependent roles during fracture healing.

This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Fold change in the expression western blot analysis of osteopontin protein considering protein expression in sample collected at first time as basal level.

Osteogenic potential of cissus qudrangularis assessed with osteopontin expression

From these results, it is postulated that a dose of g Cissus Quadrangularis daily is free from observable side-effects. Subchronic toxicity of Cissus quadrangularis Linn. Author information Copyright and License information Disclaimer. Functionality in Elderly or Injured. In recent years, bbone and traditional uses of natural compounds, especially of plant origin received much attention as they are well-tested for their efficacy and generally believed to be safe for human use.


Cissuw of Cissus quadrangularis Linn. Each scan consisted of slices with an exposure time of 30 seconds per slice.

Cissus quadrangularis – Scientific Review on Usage, Dosage, Side Effects |

CissksCissus quadrangularisHadjodosteogenic agent. There were no changes in the bone at the tibio-fibular junction between groups. Paste of alcoholic extract of the plant was locally as well as intramuscularly facilitates rapid healing of fracture in albino rats.

A total of 60 patients of simple mandible fracture were included in this study and patients were randomly divided into two groups 30 patients in each group. In the distal femoral metaphysis, femoral diaphysis, and proximal tibia, control mice had decreased cancellous and cortical bone, while CQ-fed mice showed no significant differences in the trabecular number, quadrangulariis, and connectivity density, between Sham and OVX mice, except for cortical bone mineral content hone the proximal tibia.

The use of sap with tamarind has been reported in East Africa for the treatment of gonorrhoea.

It is popular as a joint aid for athletes, with preliminary evidence supporting this property of cissus. Since the plant Cissus quadrangularis Linn is useful in the traditional quaerangularis of medicine in treatment of various diseases, it is important to standardize it for use as a drug.

The capsules of Cissus were ckssus from any pesticides, chemicals, and heavy metals. Efficacy of Cissus quadrangularis on early ossification and remodeling of bones have been reported and it has been observed that Cissus quadrangularis acts by stimulation of metabolism and increased uptake of the minerals calcium, sulpher and strontium by the osteoblasts in fracture healing.

This hastening in the fracture healing was attributed cisssus the stimulation of all the cells of mesenchyma origin, namely the fibroblasts, the chondroblasts and osteoblasts by Cissus quadrangularis. African Journal of Biomedical Research ; 8: The hone plant including all parts such as stems, leaves, roots are documented to possess medicinal properties in ethnobotanical surveys conducted by ethnobotanists in traditional system of medicine.

View at Google Scholar A. Quacrangularis studies where at least two are double-blind and placebo controlled. Article Information Sr No: In biochemical analysis, serum calcium level and alkaline phosphatase level were significantly increased in Cissus group. It is a fleshy, cactus-like liana widely used as a common food item in India. Pathways and site of action of a phytogenic steroid from Cissus quadrangularis.


Determination of marker constituents from Cissus quadrangularis Linn. It will be interesting to see if CQ has any influence on the adipocytes found in the bone marrow.

Another study utilizing Cissus standardized to 2. Cissus quadrangularis bkne CQ O: Phytochemical study of Cissus quadrangularis. Fracture of maxillofacial skeletal takes reasonably long time to heal. The physical constant evaluation is an important parameter in detecting adulteration or improper handling of the drug.

Journal of Osteoporosis

This will stimulate the cells of mesenchymal origin, namely the fibroblasts, the chondroblasts, and the osteoblasts by C. Results Pain and swelling gradually reduced in C.

Please review our privacy policy. Systemic use of Cissus quadrangularis in rats caused complete restoration of normal composition of bone, after fracture in four weeks while the controls required six weeks. It also contains two steroidal principles — 1. An imbalance in the process of bone remodeling where there is increased bone resorption alone or in combination with decreased bone formation results in net loss of bone.

Modulatory effects of Cissus quadrangularis on periodontal regeneration by bovine-derived hydroxyapatite in intrabony defects: The study has further demonstrated that in the presence of CQ, bone mineralization takes place much earlier, when compared to that seen in its absence [ 13 ]. Systemic use of CQ in rats caused complete restoration of normal composition of bone, after fracture in 4 weeks, while the controls required 6 weeks.

Extracts of this plant are reported to contain phytoestrogenic steroids, ascorbic acid, carotene, calcium and anabolic steroids.