Salivary amylase is a gene present in humans. It is not yet known why a salivary amylase deficiency increases froguel amylase salivaire. Comme la concentration en amylase salivaire n’est pas significativement différente parmi les 4 groupes, les auteurs concluent que la présence d’hydrates de. The parotid iso-α-amylases were isoelectric at pH , , and and mixed A. Carlier, M. BonteIsoelement des isoenzymes de l’amylase salivaire par.
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Low copy number of the salivary amylase gene predisposes to obesity.
Carlsson, Andrew Walley, Evan E. Eichler, Francois Pattou, Timothy D.
Nature Genetics, March 30, Skip amylaxe content skip to menu. Paris, 27 March Saliva: Yet its number of copies can vary from one to 20, depending on the individual.
The researchers showed that people with the smallest number of salivary amylase copies and therefore low amylase levels in the blood are ten times more at risk of becoming obese.
This work, published on March 30, in Nature Genetics, reveals for the first time a genetic link between complex carbohydrate digestion and obesity. One billion people worldwide are overweight.
SALIVAIRE : Définition de SALIVAIRE
French and British researchers went further by studying obesity-discordant Swedish siblings, analyzing their genome and the genes in adipose tissue, which are expressed differently in obese subjects and in those with normal weight.
They identified a region in chromosome 1 that is unique because it contains a gene, salivary amylase AMY1present in a single form in humans. Instead of having only two copies of this gene one from the father, one from the mother the number of AMY1 copies varies in humans from one to For 10, years, since agriculture began, the number of AMY1 copies has increased, evidence of natural selection and human evolution: Researchers have noticed that people with the smallest number of AMY1 copies and therefore little amylase enzyme in salivaite blood are ten times more at risk of becoming obese.
There are two forms of amylase: Only the salivary form seems to be associated with obesity. It is not yet known why a salivary amylase deficiency increases obesity: The first is that chewing and partially digesting food in salovaire mouth could have a hormonal effect inducing satiety, which would be reduced in the case of AMY1 deficiency.
Saliva : a new trail in obesity genetics – CNRS Web site – CNRS
The second is that poor starch digestion could change the intestinal flora, thereby contributing indirectly to obesity or even diabetes. That is what initial metabolomic studies conducted in patients with high or low salivary amylase suggest 3.
Thus, individuals with low salivary amylase have abnormally high glycemia when they eat starch. These entirely novel findings point to a genetic predisposition to obesity via complex carbohydrate digestion and its effects on the intestinal bacterial flora.
They open important swlivaire for more effective obesity prevention and treatment that take into account food digestion and degradation in the intestines.